GPAT/NIPER: Detailed tutorial on solubility

The solubility is expressed as solute or solvent that is a basic a no understanding of solubility I will just read out for yourself it is the property of the solid liquid or gaseous chemical substance it’s the property of solid liquid or gaseous chemical substance called solute to dissolve in a solid liquid or gaseous solvent so the Eiger concept is solute in solvent is nothing but solubility so normally if as for the u.s. pharmacopoeia if solute is one part then it depends upon how many parts of solvent is required to solubilize that solute and that govern is solubility for example is the the solvent part is less than one it is known as very soluble okay then if it is want to ten okay it is known as freely soluble then 10 to 30 it is known as only soluble okay just soluble then 3200 this one can Gpad question sparingly soluble sparingly okay and insoluble then 100 mm slightly soluble thousand to ten thousand very slightly soluble and more than ten thousand it is practically

Enhancement of water solubility of poorly water-soluble drugs by ...

insoluble okay so strong ability can be determined by the balance of intermolecular force between solute and the solvent see you can refer to our earlier intermolecular force video there is an interaction between solute and solvent and that stabilizes that forces actually govern their solubility okay if there is only one part less than one part is required so that means the solute and solvent is happily interacting with them and to get dissolved in any so that’s why the intermolecular forces at least very vital important role in the suddenly now after that what other factors can influence solubility number one physical chemical and physical chemical properties of solute that I’m come to very soon when I discussed with physical chemical properties video ok that I will explain there after that what are the factors then temperature pressure and the pH of the medium okay as I already expressed explained pH and PK relationship I’ll be making very soon the percent ionization concept video ok that’s what so very important for Gpad and after that solubility also depends upon the dielectric constant of solvent dielectric constant of solvent dielectric constant of solvent now if I just bifurcate directly constant you know those various region like starting from one point eight nine to nine point one go to from twenty then I’ll extend to thirty seven point five point five then I extend to 47:58 47:58 the last one is seventy nine point seven seventy nine point seven so this is the dielectric constant that I perfect I perfected it so first one is nonpolar lipophilic nonpolar and lipophilic solvents okay now for example 1.89 it is your hexane okay pigs in a 9.1 is your dichloromethane I’ll just write that on the value 20 is acetone okay 37 point 5 it is a c2 nitride éxito nitride and xlvii means your DMSO dimethyl sulfoxide 58 is your formic acid formic acid is not a solvent but we use them whenever we want to adjust the pH okay it’s the buffer okay yes I will make the video on boxcar and percent ionization okay in that I will clear the hiset more so then the next thing is seventy nine point seven that is the water okay so now nonpolar die fulfilling okay in between the range what are the solvent comes after hexane the petroleum is her dioxin benzene toluene dietary third is higher acetate and tetra hydro fuel on okay then after that it is over the fulfilling molar but look awful like an example you have dichloromethane acetone these two major solvent then after that you have twenty to thirty seven point five it is polar lipophilic so you have to pull a little filly then it is high to have knowing polar hydrophilic non polar nonpolar but it is hydrophilic okay so non polar hydrophilic you have know this your hydrophilic even this polar one way I should not pull the hydrophilic don’t put our hydrophilic without okay voila I will say lipophilic okay nine point one twenty so what this ethanol come it all comes is after 2020 to 2025 that mean is hydrophilic okay this is ethanol and methanol it is hydrophilic and it is having a non polar nature so definitely the the compounds having the weak polarity they also can be resolved in the methanol and ethanol okay of course methanol is more polar than ethanol because it’s an all contained more number of carbon if you increase the number of carbon then you know the the hydrophilic city can goes to the lipophilic quadrant okay now after that from the hydrophilic nonpolar after that you can write the rest of the thing polar hydrophilic these are the polar hydrophilic solvents polar hydrophilic so that’s why you have DMSO okay acetonitrile is also towards the hydrophilic so this concept is very important for your chromatography because chromatography is all about you know deals with the mobile says okay now call the now you’ll come to the like some salt if it is dissolved in a solvent okay sodium less steel – solubility and you see if I write stalling as a a X B Y dissociated as it’s a y + + V – X sorry Y into B minus X okay so then the dissociation rate constant will be X a a plus y into X into B minus 6y ^ y upon a X into B 1 okay so this is your rate constant if you multiply this going to X into B 1 into X into B Y that become a solubility product KSP so solubility product if the salt is having high solubility product that dissociation also high and that’s all you are so high in the solvent now there is a next factor which affect your solubility note is known as common ion effect common ion effect now if you have you put two different type of salt which have a common ion like chloride okay like sodium culinary and silver chloride okay you have a next year I didn’t have a this year now the thing is that solubility the solubility product of NaCl is higher than existence so this dissociation of NaCl is much more so AG CL what happened when sodium chloride dissociates much more so chloride ion is given by the sodium chloride is much more in the solution so that chloride and suppress the GCL dissociation because it’s a common ion effect and that’s why you can find that silver chloride solution if you add some sodium chloride will get precipitate out PPT okay and that’s when I starting out that we’ll be discussing in our physical pharmacy videos now after that if you decrease the particle size it increases the surface area increases the solubility now there are that is a Randolph equation which relate solubility equilibrium constants

GPAT/NIPER: Detailed tutorial on solubility

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